氧感應(yīng)通路與腫瘤細(xì)胞對放療和化療的耐藥作用相關(guān)。隨著腫瘤的生長，腫瘤細(xì)胞可以感應(yīng)到環(huán)境中氧氣的緊張并重新編程與癌細(xì)胞生存和治療抵抗密切相關(guān)的關(guān)鍵途徑。這種重新編程的其中一個(gè)例子是通過上調(diào)缺氧誘導(dǎo)因子α（HIF-alpha）和激活HIF信號下游通路。

張博士的實(shí)驗(yàn)室主要致力于研究氧感應(yīng)通路，以及它們?nèi)绾未龠M(jìn)腫瘤的發(fā)展以及治療耐藥。張博士的實(shí)驗(yàn)室正在實(shí)施新的基因組和蛋白質(zhì)組學(xué)方法，以確定乳腺癌和腎癌中氧感應(yīng)信號的重要新治療靶點(diǎn)。在本次云講堂直播間，張博士將為我們帶來圍繞氧感應(yīng)通路而發(fā)現(xiàn)的治療新靶點(diǎn)，包括乳腺癌新靶點(diǎn)BBOX1以及腎癌新靶點(diǎn)ZHX2、SFMBT1、TBK1等。

09月10日晚19:00--20:00，張青教授將為我們帶來《乳腺癌和腎癌治療新靶點(diǎn)的發(fā)現(xiàn)和確證》，歡迎大家準(zhǔn)時(shí)收看！

Hypoxia is associated with resistance towards radiation and chemotherapy. As tumors grow, they can sense the oxygen tension and reprogram critical pathways that are important for cancer cell survival and therapy resistance. One of examples is through upregulation of hypoxia inducible factor alpha (HIF-α) and activation of HIF signaling downstream pathways. Dr. Zhang’s lab is mainlyinterested in studying the oxygen-sensing pathway and how they contribute tothe development of tumors as well as therapeutic resistance. Dr. Zhang’s lab is implementing novel genomic and proteomic approaches to identify important new therapeutic targets in oxygen sensing signaling in breast and kidney cancers. During this talk, Dr. Zhang will present on identifying BBOX1 as a new therapeutic target in breast cancer. In addition, Dr. Zhang will present on identifying a few new therapeutic targets in kidney cancer, including ZHX2,SFMBT1 and TBK1.