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搜索結(jié)果包含 cell apoptosis 的內(nèi)容

Aug 21,2023
TAK-931是一種高效的CDC7抑制劑,通過(guò)抑制CDC7來(lái)抑制DNA復(fù)制,具有抗腫瘤功效,體內(nèi)藥效研究通過(guò)美迪西進(jìn)行
Replication stress (RS) is a cancer hallmark; chemotherapeutic drugs targeting RS are widely used as treatments for various cancers. To develop next-generation RS-inducing anticancer drugs, cell divis
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TAK-931是一種高效的CDC7抑制劑,通過(guò)抑制CDC7來(lái)抑制DNA復(fù)制,具有抗腫瘤功效,體內(nèi)藥效研究通過(guò)美迪西進(jìn)行
Jul 06,2023
IAP蛋白是有吸引力的癌癥治療靶點(diǎn)。SM-406 是一種口服有效的IAP拮抗劑。SM-406 在雄性SD大鼠、比格犬和NHP中的PK研究通過(guò)美迪西進(jìn)行
Apoptosis is a cellular process critical to the normal development and homeostasis of multicellular organisms.?The inhibitor of apoptosis proteins (IAPs) are a class of key apoptosis regulators.
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IAP蛋白是有吸引力的癌癥治療靶點(diǎn)。SM-406 是一種口服有效的IAP拮抗劑。SM-406 在雄性SD大鼠、比格犬和NHP中的PK研究通過(guò)美迪西進(jìn)行
Jul 06,2023
設(shè)計(jì)合成一系列用于治療胃癌的多靶點(diǎn)受體酪氨酸激酶抑制劑,并進(jìn)行生物學(xué)評(píng)價(jià)。其中藥代動(dòng)力學(xué)分析通過(guò)美迪西進(jìn)行
Gastric cancer is the second most lethal cancer across the world. Compounds 8f, inhibits FGFR1 signaling pathways as well as induces cell apoptosis, is a potential agent for the treatment of gastric c
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設(shè)計(jì)合成一系列用于治療胃癌的多靶點(diǎn)受體酪氨酸激酶抑制劑,并進(jìn)行生物學(xué)評(píng)價(jià)。其中藥代動(dòng)力學(xué)分析通過(guò)美迪西進(jìn)行
Jul 06,2023
AD80是一種多激酶抑制劑,在多種肝細(xì)胞癌臨床前動(dòng)物模型中具有抗腫瘤活性,AD80在血漿中的含量通過(guò)美迪西進(jìn)行LC-MS/MS測(cè)定
Liver cancer is the fourth greatest cause of cancer related mortality. AD80 is a multi-kinase inhibitor with anti-tumoral activity across a variety of hepatocellular carcinoma (HCC) preclinical models
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AD80是一種多激酶抑制劑,在多種肝細(xì)胞癌臨床前動(dòng)物模型中具有抗腫瘤活性,AD80在血漿中的含量通過(guò)美迪西進(jìn)行LC-MS/MS測(cè)定
Jul 06,2023
氯磺丙脲對(duì)蠕蟲(chóng)和人肺成纖維細(xì)胞MRC-5細(xì)胞具有抗衰老作用,氯磺丙脲在小鼠中的生物利用度測(cè)定通過(guò)美迪西進(jìn)行
Sulfonylureas exert their anti-diabetic effects by inhibiting K-ATP channels in the plasma membrane of islet β-cells. Chlorpropamide acts on complex II directly or indirectly via mitoK-ATP to produce
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氯磺丙脲對(duì)蠕蟲(chóng)和人肺成纖維細(xì)胞MRC-5細(xì)胞具有抗衰老作用,氯磺丙脲在小鼠中的生物利用度測(cè)定通過(guò)美迪西進(jìn)行
Jul 06,2023
SKLB-YTH-60可改善博來(lái)霉素誘導(dǎo)的肺纖維化小鼠模型中的炎癥和纖維化,YTH-60的體內(nèi)藥代動(dòng)力學(xué)研究通過(guò)美迪西進(jìn)行
Idiopathic pulmonary fibrosis is a chronic and lethal lung disease associated with fibroblast activation, myoblast proliferation and extracellular matrix deposition. SKLB-YTH-60 was developed through
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SKLB-YTH-60可改善博來(lái)霉素誘導(dǎo)的肺纖維化小鼠模型中的炎癥和纖維化,YTH-60的體內(nèi)藥代動(dòng)力學(xué)研究通過(guò)美迪西進(jìn)行
Jul 05,2023
阿帕替尼通過(guò)VEGFR2通路抑制紫杉醇對(duì)胃癌細(xì)胞的耐藥性
Overexpression of VEGFR2 can offset the rescue effect of Apatinib on Paclitaxel-induced drug resistance of MGC803 cells. Apatinib inhibits Paclitaxel resistance of MGC803 cells via the VEGFR2 #signali
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阿帕替尼通過(guò)VEGFR2通路抑制紫杉醇對(duì)胃癌細(xì)胞的耐藥性
Jul 05,2023
研究人員報(bào)告了一種具有細(xì)胞滲透性的選擇性METTL3納摩爾抑制劑UZH1a,作者感謝美迪西合成了UZH1a和UZH1b
The methylase METTL3 is the writer enzyme of the N6‐methyladenosine (m6A) modification of RNA.Here researchers report a nanomolar inhibitor of METTL3 (UZH1a) which is selective and cell‐permeable, whi
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研究人員報(bào)告了一種具有細(xì)胞滲透性的選擇性METTL3納摩爾抑制劑UZH1a,作者感謝美迪西合成了UZH1a和UZH1b
Jul 05,2023
RIPK2激酶參與多種慢性炎癥,UH15-15抑制RIPK2激酶并具有良好的體外ADME和PK特性,PK研究通過(guò)美迪西進(jìn)行
Receptor interacting protein kinase-2 (#RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain cell signaling, a pathway implicated in numerous
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RIPK2激酶參與多種慢性炎癥,UH15-15抑制RIPK2激酶并具有良好的體外ADME和PK特性,PK研究通過(guò)美迪西進(jìn)行
Jul 05,2023
合成具有體內(nèi)抗腫瘤活性的強(qiáng)效PD-L1抑制劑,并進(jìn)行生物學(xué)評(píng)價(jià)和機(jī)制研究。PK研究通過(guò)美迪西進(jìn)行
PD-1 and PD-L1 have been very successful for the treatment of various tumors, including NSCLC, urothelial cancer, melanoma, head and neck squamous cell cancer, and lymphoma. Researchers identified com
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合成具有體內(nèi)抗腫瘤活性的強(qiáng)效PD-L1抑制劑,并進(jìn)行生物學(xué)評(píng)價(jià)和機(jī)制研究。PK研究通過(guò)美迪西進(jìn)行
Jul 05,2023
zapERtrap:光調(diào)節(jié)的內(nèi)質(zhì)網(wǎng)釋放系統(tǒng)揭示了意想不到的神經(jīng)元運(yùn)輸途徑,Zapalog的合成通過(guò)美迪西進(jìn)行
zapERtrap opens the door to previously unapproachable questions concerning how proteins are processed, trafficked, and secreted in space and time in complex cellular environments. zapERtrap relies on
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zapERtrap:光調(diào)節(jié)的內(nèi)質(zhì)網(wǎng)釋放系統(tǒng)揭示了意想不到的神經(jīng)元運(yùn)輸途徑,Zapalog的合成通過(guò)美迪西進(jìn)行
Jul 05,2023
研究人員使用RZ-2994來(lái)表征抑制SHMT1/2在T細(xì)胞急性淋巴細(xì)胞白血病 (T-ALL) 中的作用,RZ-2994通過(guò)美迪西定制合成
Despite progress in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) has limited treatment options, particularly in the setting of relapsed/refractory disease. Researchers used SHMT1/2 inh
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研究人員使用RZ-2994來(lái)表征抑制SHMT1/2在T細(xì)胞急性淋巴細(xì)胞白血病 (T-ALL) 中的作用,RZ-2994通過(guò)美迪西定制合成
Jul 05,2023
研究人員開(kāi)發(fā)了一種高特異性的CDC7抑制劑TAK-931作為臨床腫瘤治療劑,抗腫瘤藥效研究通過(guò)美迪西進(jìn)行
Cell division cycle 7 (CDC7) plays important roles in DNA replication. Researchers developed a highly specific CDC7 inhibitor, TAK-931, as a clinical cancer therapeutic agent. The antitumor efficacy s
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研究人員開(kāi)發(fā)了一種高特異性的CDC7抑制劑TAK-931作為臨床腫瘤治療劑,抗腫瘤藥效研究通過(guò)美迪西進(jìn)行
Jul 05,2023
設(shè)計(jì)、合成和評(píng)估具有體內(nèi)抗炎活性的RIPK1抑制劑,PK研究通過(guò)美迪西進(jìn)行
RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, researchers r
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設(shè)計(jì)、合成和評(píng)估具有體內(nèi)抗炎活性的RIPK1抑制劑,PK研究通過(guò)美迪西進(jìn)行
Jun 28,2023
ARD-2128是一種PROTAC AR降解劑,具有出色的血漿和微粒體穩(wěn)定性,體外穩(wěn)定性和PK研究通過(guò)美迪西進(jìn)行
ARD-2128 has excellent plasma and microsomal stability in all the five species (Human, Mouse, Rat, Dog, and Monkey). The in vitro stability and pharmacokinetic (PK) studies were performed by Medicilon.
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ARD-2128是一種PROTAC AR降解劑,具有出色的血漿和微粒體穩(wěn)定性,體外穩(wěn)定性和PK研究通過(guò)美迪西進(jìn)行
Jun 28,2023
放射療法用作肺癌的主要治療方法,在次研究中建立抗電離輻射肺癌細(xì)胞系的放射治療通過(guò)美迪西進(jìn)行
Radiation therapy is used as the primary treatment for lung cancer. In this study, radiation therapy for establish ionizing radiation-resistant lung cancer cell lines (A549-IR/H1299-IR) was supported by Medicilon.
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放射療法用作肺癌的主要治療方法,在次研究中建立抗電離輻射肺癌細(xì)胞系的放射治療通過(guò)美迪西進(jìn)行
Jun 28,2023
CAR-T療法主要針對(duì)白血病與惡性淋巴瘤,此研究中構(gòu)建沉默PD-1的shRNA載體質(zhì)粒,測(cè)序后質(zhì)粒的鑒定通過(guò)美迪西進(jìn)行
Chimeric antigen receptor T cells (CAR-T) immunotherapy has shown promising clinical results in the treatment of leukemia and lymphoma, but the effectiveness is limited for solid tumors. The shRNA vector plasmid that silences PD-1 and preparation of CAR i
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CAR-T療法主要針對(duì)白血病與惡性淋巴瘤,此研究中構(gòu)建沉默PD-1的shRNA載體質(zhì)粒,測(cè)序后質(zhì)粒的鑒定通過(guò)美迪西進(jìn)行
Jun 28,2023
GS-5801是一種有效的KDM5抑制劑,具有抗HBV活性,GS-5801通過(guò)美迪西合成
GS-5801, a potent inhibitor of KDM5, has antiviral activity against HBV in a primary human hepatocytes infection model, with the cellular permeability, oral bioavailability. GS-5801 was synthesized by Medicilon.
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GS-5801是一種有效的KDM5抑制劑,具有抗HBV活性,GS-5801通過(guò)美迪西合成
Jun 28,2023
TR-107是人類線粒體蛋白酶ClpP的有效激活劑,PK分析通過(guò)美迪西進(jìn)行
The pharmacokinetic properties of TR‐107 were compared with other known ClpP activators including ONC201 and ONC212. TR‐107 displayed excellent exposure and serum t1/2 after oral administration. Pharmacokinetic analysis were evaluated for pharmacokinetic
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TR-107是人類線粒體蛋白酶ClpP的有效激活劑,PK分析通過(guò)美迪西進(jìn)行
Jun 16,2022
美迪西邀您相聚SAPA美國(guó)2022細(xì)胞&基因治療年會(huì)
美迪西陳春麟博士及美國(guó)商務(wù)團(tuán)隊(duì)將于 6 月 17 日至 18 日參加 Cell & Gene Therapy Annual Conference。屆時(shí)將與參會(huì)的眾嘉賓進(jìn)行詳細(xì)交談,共同探討我們的專業(yè)服務(wù)如何更快地加速各企業(yè)的藥物研發(fā)過(guò)程!
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美迪西邀您相聚SAPA美國(guó)2022細(xì)胞&基因治療年會(huì)
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